Abstract
Doxorubicin (DOX), a chemotherapeutic drug, often causes many adverse side effects in patients with cancer, such as weight loss, motor disability, blood circulation defects, myelosuppression, myocardial injury, joint degeneration, and bone loss. The Chinese herbal medicine Guilu Erxian Glue (GEG) has been used in the prevention and treatment of osteoarthritis and osteoporosis for hundreds of years, with considerably fewer side effects. We expected that GEG could serve as a protective and beneficial alternative treatment for DOX-induced adverse side effects. In this study, we evaluated whether GEG can alleviate DOX-induced weight loss, motor disability, abnormal blood circulation, myelosuppression, myocardial injury, joint degeneration, and bone loss by using chemotherapy models of synoviocyte cell line HIG-82 and mice. Moreover, we examined the antioxidant capacity of GEG by using DPPH (1,1-diphenyl-2-picrylhydrazyl) free-radical scavenging. Our results revealed that GEG treatment can significantly enhance DPPH free-radical scavenging and reduce DOX-induced cytotoxicity in synoviocyte HIG-82 cells. In addition, GEG treatment for 2 weeks can significantly relieve weight loss, enhance exhaustive exercise capacity, improve blood circulation, alleviate myocardial oxidative stress and inflammation, and strengthen the tibias of DOX-treated mice. Thus, we suggest that GEG treatment can be a protective and alternative therapy for alleviating chemotherapy-related side effects such as weight loss, motor disability, blood circulation defects, and bone loss.
Highlights
Patients with cancer undergoing chemotherapy often report many adverse side effects, such as weight loss, motor disability, blood circulation defects, myocardial injury, joint degeneration, and bone loss [1,2,3,4,5,6,7,8,9,10]
We mainly investigated the alleviating effects of Guilu Erxian Glue (GEG) treatments in DOX-induced cytotoxicity in synoviocyte cell line HIG-82 and on weight loss, motor disability, blood circulation defects, myelosuppression, myocardial injury, and bone loss in mice subjected to chemotherapy
GEG is a combination of traditional Chinese medicine with four main ingredients of ginseng (Radix Ginseng), wolfberry (Fructus Lycii), tortoise plastron (Carapax et Plastrum Testudinis), and antler (Cornu Cervi) from a famous Chinese prescription
Summary
Patients with cancer undergoing chemotherapy often report many adverse side effects, such as weight loss, motor disability, blood circulation defects, myocardial injury, joint degeneration, and bone loss [1,2,3,4,5,6,7,8,9,10]. Oxidative stress and inflammation were reported to be involved in the pathogenesis of DOX-induced cardiotoxicity [12,13,14,15,16,17,18]. Increased oxidative stress can reduce mitochondria activity and lead to apoptosis [19, 20]. Our previous study revealed that DOXtreated mice exhibited myocardial oxidative stress, inflammation, and apoptosis, whereas the herbal formula B307
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