Abstract
Objective: This study investigated the effects of Chinese herbal medicine and prednisone on CD4+FoxP3+ T cells (Tregs) and Th17 cells in the MRL/lpr mouse model of systemic lupus erythematosus. 
 Methods: MRL/lpr mice were treated with herbal medicine (yin-nourishing and heat-clearing therapy), prednisone, and a combination of both for 7 weeks. The proportions of CD4+CD25+FoxP3+ cells, CD4+CD25-FoxP3+ cells, and CD4+IL-17+ cells in splenic mononuclear cell suspension were determined by flow cytometry. Histological slices of kidneys were stained by H&E, PAS, and Masson’s method. Activity indexes (AI) of glomerular lesions were scored. 
 Results: The result showed that both herbal medicine and prednisone significantly increased the proportion of CD4+CD25-FoxP3+ cells (P
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: African Journal of Traditional, Complementary and Alternative Medicines
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
