Abstract
Chimps, Humans, and the Hominid Struggle against Viruses.
Highlights
The human immunodeficiency virus (HIV) is one virus that engages in such an arms race, and it’s known that one of the strongest genetic determinants of how HIV infection progresses is which version of one particular major histocompatibility complexes (MHCs) class I gene an individual has
In the case of class I MHCs, positive recognition by a passing cytotoxic T cell can result in the peptide-displaying cell being targeted for destruction
The human immunodeficiency virus (HIV) is one virus that engages in such an arms race, and it’s known that one of the strongest genetic determinants of how HIV infection progresses is which version of one particular MHC class I gene an individual has
Summary
The human immunodeficiency virus (HIV) is one virus that engages in such an arms race, and it’s known that one of the strongest genetic determinants of how HIV infection progresses is which version of one particular MHC class I gene an individual has. One reason for this protective effect is presumed to be that peptides from the HIV Gag protein fit snugly into the groove of the HLA-BÃ57:01 version of the MHC, where they can be spotted by cytotoxic T cell receptors.
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