Abstract
Results Fecal levels of HNP1-3 and HBD2 decreased from 3 to 6 months. Low HNP1-3 and high HBD2 levels at 6 months were associated with allergy and sensitisation by the age of 5 years (p<0.05). HNP1-3 levels correlated negatively with a1-antitrypsin levels at the age of 3 months (coefficient -0.5; p<0.05) in children who developed sensitisation only or combined with allergic disorders. HBD2 levels correlated positively with TNF-a (0.7; p<0.05) in children with subsequent IgE-mediated allergy. Probiotic treatment tended (p<0.06) to increase fecal HBD2 levels at the age of 6 months compared with placebo. Conclusions Early innate immunity responses in the gut are associated with the emergence of allergy later in childhood.
Highlights
Since early innate immunity responses and the intestinal flora guide adaptive immune responses, we investigated whether fecal defensin levels in infancy were associated with the emergence of allergy
In a randomized, double-blind placebo-controlled trial, 1018 infants in high risk for allergy received from birth to 6 months either a mixture of pre- and probiotics, or placebo
Early innate immunity responses in the gut are associated with the emergence of allergy later in childhood
Summary
Since early innate immunity responses and the intestinal flora guide adaptive immune responses, we investigated whether fecal defensin levels in infancy were associated with the emergence of allergy. Children who develop allergy have low fecal alpha-defensin levels but high beta-defensin levels in infancy Emma Savilahti*, Anna Kaarina Kukkonen, Tari Haahtela, Mikael Kuitunen, Erkki Savilahti From Food Allergy and Anaphylaxis Meeting 2011 Venice, Italy.
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