Abstract

Knowledge of anorexia nervosa (AN) in childhood is scarce. This review gives a state-of-the-art overview on the definition, classification, epidemiology and etiology of this serious disorder. The typical features of childhood AN in comparison to adolescent AN and avoidant restrictive eating disorder (ARFID) are described. Other important issues discussed in this article are somatic and psychiatric comorbidity, differential diagnoses and medical and psychological assessment of young patients with AN. Special problems in the medical and psychological treatment of AN in children are listed, although very few studies have investigated age-specific treatment strategies. The physical and mental outcomes of childhood AN appear to be worse than those of adolescent AN, although the causes for these outcomes are unclear. There is an urgent need for ongoing intensive research to reduce the consequences of this debilitating disorder of childhood and to help patients recover.

Highlights

  • Anorexia nervosa (AN) is a serious and often chronic disorder with a peak incidence in adolescence. childhood AN has long been recognized and described in several case studies [1,2], knowledge of the diagnosis and treatment has become increasingly important due to the rising admission rates of childhood AN in several European countries

  • Childhood will be defined as aged below 14 years, as this corresponds to the age span used in many investigations of young people with AN and will include premenarchal and postmenarchal onset of the disorder

  • In the UK [11], the prevalence of AN in 10 to14-year-olds rose from 2.5/100,000 total children to 7.5/100,000 during the last two decades; the German health care statistics indicate an increase of patients below 15 years from seven to 13 from the year 2000 to the year 2017 (German Federal Statistics, http://www.gbe-bund.de/, assessed July 2019)

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Summary

Introduction

Anorexia nervosa (AN) is a serious and often chronic disorder with a peak incidence in adolescence. The same diagnostic criteria for AN should be applied to all age groups, there are differences in the presentation, epidemiology, medical and psychiatric comorbidities, as well as outcomes between younger and older patients. The aim of this article is to give a thorough overview of the diagnosis, including behavioral and physical features of childhood AN, as well as of treatment and outcomes of the disorder. We seek to underline the typical differences between onset in childhood and adolescence. Childhood will be defined as aged below 14 years, as this corresponds to the age span used in many investigations of young people with AN and will include premenarchal and postmenarchal onset of the disorder. Age below 14 years is the legal age-definition of childhood in Germany

Definition and Diagnosis
Epidemiology
Symptomatology
Symptoms and Complications
Endocrine Changes
Endocrinemay changes in childhood
Growth and Body Height
Amenorrhea and Resumption of Menses
Impact on the Brain
Psychological Assessment
Differential Diagnosis
Psychiatric Comorbidity
10.1. Biological Risk Factors
10.2. Sociocultural Risk Factors
11. Treatment
11.1. Medical Treatment
11.2. Medication
11.3. Hormone Replacement Therapy
11.4. Psychological Treatments
12. Outcome
Findings
13. Conclusions

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