Childhood trauma but not FKBP5 gene variants associated with peritraumatic dissociation in female rape survivors

Abstract

IntroductionPeritraumatic dissociation has been shown to be a strong predictor for development of PTSD. ObjectiveThis study explored the relationship of four putative FK506 binding protein 5 (FKBP5) genetic variants and childhood trauma in predicting peritraumatic dissociation. MethodExtracted DNA from 81 female rape survivors in Cape Town, South Africa were analysed for common FKBP5 polymorphisms. Dissociative experiences, childhood trauma, depression and resilience were also measured. ResultsChildhood trauma was associated with a significant increase in peritraumatic dissociation, whilst resilience conferred a significant protective effect. No significant associations were observed between the single loci or haplotypes under investigation and peritraumatic dissociation. ConclusionThis study provides evidence that, among female rape survivors, exposure to childhood trauma may increase risk of peritraumatic dissociation independent of genetic variation of the FKBP5 gene.