Abstract
Childhood eating behaviour contributes to the rise of obesity and related noncommunicable disease worldwide. However, we lack a deep understanding of biochemical alterations that can arise from aberrant eating behaviour. In this study, we prospectively associate longitudinal trajectories of childhood overeating, undereating, and fussy eating with metabolic markers at age 16 years to explore adolescent metabolic alterations related to specific eating patterns in the first 10 years of life. Data are from the Avon Longitudinal Study of Parents and Children (n = 3104). We measure 158 metabolic markers with a high-throughput (1H) NMR metabolomics platform. Increasing childhood overeating is prospectively associated with an adverse cardiometabolic profile (i.e., hyperlipidemia, hypercholesterolemia, hyperlipoproteinemia) in adolescence; whereas undereating and fussy eating are associated with lower concentrations of the amino acids glutamine and valine, suggesting a potential lack of micronutrients. Here, we show associations between early behavioural indicators of eating and metabolic markers.
Highlights
Childhood eating behaviour contributes to the rise of obesity and related noncommunicable disease worldwide
We investigate if the relationship between eating behaviour in childhood and metabolic markers in adolescence at 16 years is mediated through body mass index (BMI) measured at 12 years of age
In 3104 adolescents, a subsample of the original ~ 14,000 Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (Table 1), we test the prospective association between parent-reported eating behaviour in the first ten years of life (Fig. 1a–c) and metabolic profiles at the age of 16 years
Summary
Childhood eating behaviour contributes to the rise of obesity and related noncommunicable disease worldwide. Children living in an obesogenic environment[10] are exposed to highly palatable, energy dense food while being sedentary most of the time[11] Individuals with obesity have higher lipid concentrations than those at normal w eight[19] and early alterations in metabolic profiles associated with obesity can be observed in c hildhood[20]. These preliminary findings suggest that metabolic markers are potential biomarkers of noncommunicable disease in children
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