Childhood Core Binding Factor (CBF) acute myeloid leukaemia and its association with French American British (FAB) classification.

Abstract

To find the frequency of core binding factor acute myeloid leukaemia in our population, and to determine its association with morphological subtypes. The retrospective study was conducted at The Indus Hospital, Karachi, and comprised data of patients aged 1-17 years who were diagnosed with acute myeloid leukaemia from July 2013 to June 2017. Data was analysed using SPSS 21. Of the 237 patients, 137(58%) were males and 100(42%) were females. The overall mean age was 8±4.34 years. Cytogenetic testing had been performed in 212(89.45%) cases, and core binding factor was detected in 72(34%) cases. There was significant difference between the mean values of white cell count and the subtypes (p=0.000). Also the difference between core binding factor and the subtypes was significant (p=0.000). There was found to be a significant association of core binging factor with specific subgroups of acute myeloid leukaemia.