Abstract
Childhood Body Size and Premenstrual Disorders—Is There an Association?
Highlights
Studies that use secondary data sources are limited by the availability of data, which may exclude some important potential confounders. This limitation raises the concern that the results may have been biased by unmeasured confounders associated with both body mass index (BMI) and premenstrual syndrome (PMS)
The authors controlled for several important confounders, their adjustment for the history of psychological trauma was limited to child abuse, which was only available for GUTS 1 cohort participants, whereas the GUTS 2 cohort was missing information on this potential common cause
Dietary factors that may be associated with BMI and Premenstrual disorders (PMDs), including intake of several minerals,[5] were not sufficiently controlled for, raising additional concerns of residual confounding
Summary
Claims of causal associations are generally not accepted from observational studies, yet, as VanderWeele[3] argues, carefully designed and analyzed longitudinal studies may provide strong evidence in support of a causal relationship. Studies that use secondary data sources are limited by the availability of data, which may exclude some important potential confounders.
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