Abstract
e14127 Background: Colorectal cancer (CRC) is one of the most common tumors in adults, also can occur rarely in children and young adults. Compared to adults contains significant differences in terms of symptoms, presentation, histological subgroups, localization, stage and prognosis. The aim of this study to evaluate clinicopathologic and treatment outcomes of young CRC patients. Methods: Between May 2003 to June 2010, 76 patients included in the study. The medical records studied to analyze the age, sex, presenting symptoms, presentation, family history, presence or absence of polyps, histological features, localization, stage, treatment outcomes, recurrence time and site, metastatic sites and survival outcomes. Patients were divided into two groups as; child-adolescent (0 to 19 years of age) and young adult (20 to 25 years of age). Results: A total of 76 patients (42 male, 34 female) were identified. Median age was 23 (10 to 25). Twenty two percent of patients had family history and 6.8% had presences of polyps, 24% had acute presentation, 47.4% had mucinous adenocarcinoma and 26.3% had metastatic disease. Most common symptom was abdominal pain (53.5%) and most common localization was left colon (64.5%). Statistically significant differences between the two groups in terms of sex and symptoms (p<0.05). Although there was numerically difference between the two groups no statistically significant difference for acute presentation (35.0% vs. 20.0%, p= 0.179). Patients who undergoing curative surgery shows a significant increase in survival (19.6 months vs. 3.7 months, p<0.001). Dukes B, C and D patients shows 24.5, 19.4 and 11.7 months survival, respectively (p=0.004). Patients who accepted chemotherapy after surgery (n= 52) and who rejected (n=6) shows 20.4 months and 13.0 months survival, respectively. (p=0.28). Other parameter affected survival is response to palliative chemotherapy (18.8 months vs. 11.4 months, p=0.06). Conclusions: CRC should not be excluded only on the bases of the age. Young-adult patients more similar to adults compared with child-adolescent patients. Surgery, adjuvant chemotherapy and palliative chemotherapy should be considered for appropriate patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
