Chicory root extracts reduce inflammation in vivo

Abstract

Chicory (Cichorium intybus L.) contains sesquiterpene lactones, which are thought to be potent anti-inflammatory agents. In this study, chicory extracts rich in sesquiterpene lactones significantly reduced inflammation in three animal models. In a rat paw edema model, chicory extract at 50 and 100 mg/kg significantly reduced inflammation by 58 and 76%, respectively, 24 h after carrageenan injection. In a collagen induced arthritis mouse model, chicory extract (200 mg/kg) reduced paw edema by 71% while the extract was being administered, and 31% 48 h after extract administration was discontinued. In a rat inflammatory bowel disease (IBD) model, chicory extract (300 mg/kg) reduced colon inflammation by 17% and also reduced ulceration and adhesions when IBD was induced using 2,4-dinitrobenzene sulfonic acid (DNBS). A 28-day rat toxicity study showed no signs of toxicity at doses up to 1000 mg/kg. These data demonstrate that chicory extracts rich in sesquiterpene lactones may be useful as a therapeutic agent for inflammatory disease.