Abstract
The effect of selenium enriched chickpea sprouts with and without isoflavonoids (IS) on colorectal cancer (CRC) tumor growth was evaluated in immune-suppressed mice xenografted. Two levels of selenium (0.17 and 2.29 µg/g) and isoflavonoids (0 and 2.34 mg/g) were evaluated in the diets. High intake of Se (2.29 µg/g) with and without isoflavonoids increased glutathione peroxidase (GPx) and tioredoxin reductase (TrxR) activities, cholesterol (CHOL), triglycerides (TRIGL) and low-density lipoprotein cholesterol (LDL-C) levels and decreased significantly the tumor growth. Diet containing selenium at 2.29 µg/g and isoflavonoids at 2.34 mg/g levels promoted apoptosis through the overexpression of Fas cell surface death receptor (Fas). High selenium levels in chickpea sprouts exert chemopreventive effects mediated mainly by the antioxidant protection of glutathione peroxidase. Selenized chickpea sprouts represent an excellent source of dietary selenium and isoflavonoids with chemopreventive potential and could be potentially used in the treatment of colorectal cancer.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
