Abstract
cNkx2–8 represents a novel member of the NK2-family of transcription factors. The gene contains three highly conserved regions, the TN-, NK2-, and homeodomains which are diagnostic for this group of proteins. cNkx2–8 is expressed during chick embryogenesis in ventral foregut endoderm, myocardial mesoderm, epithelium of the branchial arches and the dorsal mesocardium. While cNkx2–8 expression partially overlaps with other NK genes, such as Nkx2–5 and Nkx2–3, its onset and aspects of its expression domains are specific. Thus, structural data and the expression profile suggest that cNkx2–8 constitutes a new homeobox protein which may cooperate with its known relatives in defining an antero-ventral field including the developing heart and pharyngeal endoderm.
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