Abstract
Chicken eggs present an ideal alternative antibody source to mammals, as the IgY in the chicken’s blood is transported to the egg and accumulates in the egg yolk in large quantities. The existence of an IgG like molecule in avian eggs, referred to as IgY, has been well documented in recent studies and extensive research has been carried out on its characterization, production and purification. The yolks of eggs laid by immunized chicken have been recognized as an excellent source of polyclonal antibodies for over a decade. This simple non invasive approach presents an appealing alternative to conventional polyclonal antibody production methods. The use of immunoglobulin therapy broadens the arsenal available to combat pathogens in medicine and IgY is a promising candidate, both as an alternative to antibiotics and as a useful tool in research and diagnostics. Keywords: Chicken antibody IgY; antivenom; passive immunotherapy; Salmonella.
Highlights
Antibodies presently available for research, diagnostic and therapies are mostly mammalian monoclonal or polyclonal antibodies
Treatment with hyperimmune egg yolk (HEY) against four human rotavirus strains resulted in modest improvement of diarrhea associated with earlier clearance of rotavirus from stools. These results indicate an encouraging role of HEY in the treatment of rotavirusinduced diarrhea in children
Scientists at Vittal Mallaya Scientific Research Foundation generated antivenom specific antibodies in white leghorn chicken and their egg yolks. They recently reported that the purity, efficacy and ease of manufacture of avian antivenoms and their inability to react with mammalian complement make them an attractive alternative to equine antivenoms
Summary
A. Michael[1], S. Meenatchisundaram2*, G. Parameswari[1], T. Subbraj[1], R. Selvakumaran[3] and S. Ramalingam[4]
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