Chick vocalization and emotional behavior influenced by apomorphine.

Abstract

For the purpose of studying the role of dopamine (DA) in the causation of vocalization and other behavior in domestic chicks, 5-day-old birds were injected with 1 mg/kg doses of apomorphine hydrochloride, and their behavior was recorded by methods of direct observation. The effects of the drug on birds with bilateral lesions of the intercollicular nucleus (a vocal area) and on birds pretreated with the DA antagonists pimozide and haloperidol were also examined. In intact chicks, apomorphine induced trills, facilitated twitters, and inhibited warbles. Pecking at conspicuous objects in the cage and locomotion were increased, whereas the duration of eye closure was reduced. In chicks with lesions there was no facilitation of trills, twitters, or pecking, whereas the other drug-induced behavioral effects were as in intact chicks. Dopamine antagonists blocked the trills and twitters facilitated by apomorphine but did not protect against the inhibition of warbles. It is concluded that trills, twitters, and pecking are produced by activation of dopaminergic mechanisms. It is hypothesized that some of the behavior induced by apomorphine, especially vocalization and pecking, are a consequence of altered states of attention induced by the drug.