Cherenkov luminescence imaging of shallow sources in semitransparent media.

Sergey Komarov,Yongjian Liu,Yuan-Chuan Tai

doi:10.1117/1.jbo.24.2.026001

Sergey Komarov, Yongjian Liu + Show 1 more

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https://doi.org/10.1117/1.jbo.24.2.026001

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Abstract

.We experimentally investigated the Cherenkov luminescence imaging (CLI) of the isotopes with different beta particles energies (, , , , and ) in semitransparent biological equivalent media. The main focus of this work is to characterize the CLI when the sources are at the depth comparable with the range of beta particles. The experimental results were compared with Monte Carlo (MC) simulation results to fine tune the simulation parameters to better model the phantom materials. This approach can be applied to estimate the CLI performance for different phantom materials and isotopes. This work also demonstrates some unique properties of high energy beta particles that can be beneficial for CLI, including the possibility to utilize the betas escaped from the object for imaging purposes.

Highlights

Cherenkov luminescence imaging (CLI) is an imaging technique based on the Cherenkov effect,[1] which is an emission of electromagnetic radiation [or Cherenkov radiation (CR)] by a charged particle moving through a medium faster than phase velocity of light in that medium
In Ref. 9, the characteristics of CLI in biological tissue were characterized using results from similar Monte Carlo (MC) simulations convolved with parametrized tissue optical properties
We present an approach that uses experimental data of the sample materials to fine tune MC simulation parameters in order to estimate the CLI performance for different materials and isotopes

Summary

Introduction

Cherenkov luminescence imaging (CLI) is an imaging technique based on the Cherenkov effect,[1] which is an emission of electromagnetic radiation [or Cherenkov radiation (CR)] by a charged particle moving through a medium faster than phase velocity of light in that medium. In the studies reported by Mitchell et al and Gill et al.,[7,8] the light output from the CR in transparent media was estimated using GEANT4-based Monte Carlo (MC) simulation. In Ref. 9, the characteristics of CLI in biological tissue were characterized using results from similar MC simulations convolved with parametrized tissue optical properties.

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