Chemoviz: an Interactive Web-based Tool for Time-series Analysis of Systemic Anti-cancer Therapy: Application to Analysis of Dose Modifications of CDK4/6 Inhibitors in Clinical Practice

Abstract

Purpose: Chemotherapy prescribing systems are not routinely interrogated at unit level for clinical outcome data despite the ready availability of analysis and visualisation tools which could enable useful information to be derived. As an example, the CDK4-6 inhibitors palbociclib and abemaciclib are now used routinely in clinical practice for metastatic oestrogen receptor-positive breast cancer. Myelosuppression is often observed in clinical practice, leading to dose modification and patients not receiving as many cycles as quoted in the literature (12 cycles for palbociclib, 19 for abemacilib). Patients on palbociclib are routinely monitored with full blood counts every cycle, despite manufacturer advice to reduce this to 3-monthly after cycle 6.