Abstract
Treatment with a combination of chemotherapy and radiotherapy is known to be associated with oesophageal stricture in both children and adults with malignancies. However, oesophageal stricture resulting from chemotherapy alone is a rare complication, with few reports on it. We experienced a rare paediatric case of oesophageal stricture caused by chemotherapy for osteosarcoma of the left distal femur. After completion of the chemotherapy course, the patient showed dysphagia caused by the oesophageal stricture and underwent balloon dilatation for the oesophageal stricture. After balloon dilatation, he was able to ingest solid foods, and the oesophagus was normal without any strictures at the last follow-up (20 months after ballooning). Therefore, oesophageal stricture should be considered as a complication of treatment with chemotherapy alone in children with malignancies.
Highlights
The cure rate of paediatric malignancies has improved with the advances in both chemotherapy and radiotherapy over the last 3 decades, and the long-term survival rate is currently 80% [1]
Children with malignancies are likely to be exposed to many risk factors for oesophageal stricture during treatment, such as the administration of antineoplastic agents, radiation therapy, candidiasis, and graft versus host disease [2,3,4,5,6,7,8]
Oesophageal stricture has been reported to be caused by antineoplastic agents such as vinblastine, doxorubicin, 5-fluorouracil, and methotrexate [5, 9]
Summary
Chemotherapy-Induced Oesophageal Stricture in a Child with Osteosarcoma: A Case Report. Oesophageal stricture resulting from chemotherapy alone is a rare complication, with few reports on it. We experienced a rare paediatric case of oesophageal stricture caused by chemotherapy for osteosarcoma of the left distal femur. After completion of the chemotherapy course, the patient showed dysphagia caused by the oesophageal stricture and underwent balloon dilatation for the oesophageal stricture. After balloon dilatation, he was able to ingest solid foods, and the oesophagus was normal without any strictures at the last follow-up (20 months after ballooning). Oesophageal stricture should be considered as a complication of treatment with chemotherapy alone in children with malignancies
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