Abstract
THE use of arsenical compounds as chemotherapeutic agents against histomoniasis was first reported by Tyzzer (1923), who found that tryparsamide, atoxyl and neoarsphenamine produced a more or less favorable effect. Delaplane and Stuart (1935), however, stated that neoarsphenamine, among other compounds, was of little or no value for preventing blackhead in turkeys. Hinshaw (1937) observed that atoxyl and neoarsphenamine had been tried with but little success. He stated that tryparsamide was the only promising compound of the two and confirmed Tyzzer’s statement that it was too expensive for general use. Similar conflicting reports concerning the use of mapharsen injections have been made by Blount (1938), Bolin and Vardiman (1941), McCulloch and Nicholson (1941), Jaquette and Marsden (1947) and by Glover (1948).Well controlled experiments by Sautter, Pomeroy and Roepke (1950) have shown that injections of tryparsamide were slightly beneficial but that the effect was nullified when medication was started 4 .
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