Chemotherapy studies in non-small cell bronchogenic carcinoma

Abstract

<h2>Abstract</h2> From 1973 until 1976, several randomized and sequential studies were performed to test the activity of single drugs and combination chemotherapy in Grades I, III and IV lung cancer. Sixty-one evaluable patients received cyclophosphamide versus 5-fluorouracil. The percentage of objective responses (OR) and the median survival time (MST) was similar in both arms; 11.5% and 10.5 weeks respectively. Forty-three evaluable patients received cyclophosphamide and 5-fluorouracil; their O.R. was 11.6% and the MST was 25.5 weeks. Forty-three evaluable patients received cyclophosphamide, adriamycin and 5-fluorouracil; their O.R. was 11.6% and the MST was 23.6 weeks. It was concluded that the single drug therapy and combination chemotherapy that was used was minimally active in grade I lung cancer. No responses were observed in grades III and IV.