Abstract

Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. The agents most commonly associated with chemotherapy-associated nephrotoxicity are methotrexate, semustine, streptozocin, mithramycin, and cisplatin. Certain chemotherapeutic agents have adverse effects on the kidneys and urothelium that can be visualized radiographically, including cystic change, interstitial nephritis, papillary necrosis, urothelial changes, haemorrhagic cystitis, acute tubular necrosis, and infarction. This review focuses on imaging features identifying complications of chemotherapy in the kidneys and collecting system and provides didactic cases to alert referring clinicians.Teaching Points• Nephrotoxicity is a common adverse effect of many chemotherapeutic agents.• Chemotherapies have adverse renal and urothelial effects that can be visualized radiographically.• Crizotinib use can result in the development of complex renal cysts.

Highlights

  • PICTORIAL REVIEWChemotherapy-related complications in the kidneys and collecting system: an imaging perspective

  • Nephrotoxicity is a common adverse effect of many chemotherapeutic agents

  • This review focuses on imaging features identifying complications of chemotherapy in the kidneys and collecting system and provides didactic cases to alert referring clinicians (Table 1)

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Summary

PICTORIAL REVIEW

Chemotherapy-related complications in the kidneys and collecting system: an imaging perspective. This article is published with open access at Springerlink.com

Introduction
Cyclophosphamide Ifosphamide Busulfan Cabazitaxel
Complex renal cysts
Imaging findings
Interstitial nephritis
Renal papillary necrosis
Renal infarction
Acute tubular necrosis
Hemorrhagic cystitis
Effects of novel targeted agents on the kidney and collecting systems
Findings
Conclusion
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