Abstract
Neutrophilic eccrine hidradenitis (NEH) is a rare benign dermatological condition affecting the eccrine glands. The condition often occurs in response to chemotherapeutic agents in patients with acute myeloid leukemia (AML). However, cases of NEH are reported in patients with other malignancies and in those with non-malignant conditions. NEH is thought to result from the infiltration of neutrophils into the eccrine glands, resulting in erythematous papules and plaques on the skin. NEH is self-limiting and may resolve with cessation of the causative agent but can be treated symptomatically with steroids and analgesia. We report a case of NEH in a 52-year-old AML patient following the first cycle of chemotherapy. Following diagnosis, the patient was treated with a topical steroid and there was no recurrence. Alongside this, we uniquely present both clinical and histological images.
Highlights
We report a case of Neutrophilic eccrine hidradenitis (NEH) in a 52-year-old acute myeloid leukemia (AML) patient following the first cycle of chemotherapy
Neutrophilic eccrine hidradenitis (NEH) is a rare benign dermatological condition observed in patients with acute myeloid leukemia (AML)
90% of the cases of NEH were reported in oncology patients, 70% following their first cycle of chemotherapy [2,4]
Summary
Neutrophilic eccrine hidradenitis (NEH) is a rare benign dermatological condition observed in patients with acute myeloid leukemia (AML). NEH was originally described as a smooth lesion involving erythematous plaques and papules centimeters in size [3]. Following the first cycle of chemotherapy with cytarabine and daunorubicin, the patient developed asymptomatic juicy erythematous papules on the neck, trunk and limbs (Figure 1). The abscesses appeared to be associated with the epidermal downgrowths, with strands of mitotically active atypical squamous epithelium. How to cite this article Patel C, Jones E, Mudaliar V, et al (January 12, 2020) Chemotherapy Associated Neutrophilic Eccrine Hidradenitis, an Unusual Case with Eccrine Squamous Syringometaplasia.
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