Chemotherapy and tumor immunogenic cell death

Abstract

Chemotherapy resist is the problem for clinic, and some researches find that chemotherapy with anthracycline and oxaliplatin not only induces the tumor cell apoptosis, but also the cell immunogenic cell death (ICD) by inducing the tumor cell apoptosis and releasing three kinds of signals: exposure of calreticulin on the cell surface to stimulate the dendritic cell (DC) to engulf, and the secretion of adenosine triphosphate to recruit DC to enter into tumor bed, and the release of the high mobility group B1 to promote DC to steadily bind with dying tumor cell to induce specific T cell antitumor immune response. It is with great meaning to promote the chemotherapy protocol by studying the ICD induced by chemotherapy. Key words: Drug therapy; T-cell antigen receptor specificity; Dendritic cells; Calreticulin; Immunogenic cell death