Abstract
Abstract Several new quaternary ammonium salts have been tested for antifilarial activity against Litomosoides carinii, filarial parasite of the cotton rat. Many of these compounds are active in killing L. carinii; the most promising (BIQ 20) eicosane 1:20-bis(isoquinolinium iodide) and (BAC 20) eicosane 1:20-bis(4-aminocinnolinium iodide) possess an index (LD50 mice/minimum effective dose cotton rats) of 19 and 39 respectively. The compounds have a direct filaricidal action on the adult worms while the microfilariae are comparatively unaffected.
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