Abstract
We investigated the chemotactic responses of individual human polymorphonuclear leukocytes in defined fields of adenosine and guanosine 5′monophosphate, dibutyryl cyclic adenosine monophosphate, cyclic guanosine 3′,5′monophosphate, Kaolin and uric acid. We observed positive chemotaxis towards dibutyryl cyclic AMP, positive and negative chemotaxis towards cyclic GMP and no response towards the other chemicals. These results are discussed and compared with the known response to cyclic AMP.
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