Abstract
The chemotaxis of C. fetus subsp. venerealis and C. fetus subsp. fetus was determined in the presence of bovine cervical mucus and bovine placental extract. Some reported substances and ion in those materials, such amino acids, ferrous iron, hormones, sugars and organic acids were also investigated. Bovine cervical mucus, bovine placenta extracts and some substances and ion of these materials namely L–fucose, L– aspartate, L–glutamate, L–serine, ferrous iron, fumarate, pyruvate and succinate were chemoattractants. The chemottraction was significantly larger in higher concentrations of the tested substances and ion and significant differences among tested strains were also observed. Meso-erythritol and hormones bovine placental lactogen, 17β-estradiol, and progesterone did not elicit chemotactical response. In conclusion, this chemotactic behavior may guide the C. fetus navigation in the bovine host's genital tract and be an important cofactor of tissue tropism for this bacterium.
Highlights
C. fetus subsp. venerealis and C. fetus subsp. fetus are important cause of reproductive disorders in cattle
Since information on the C. fetus chemotaxis to substances and structures of bovine genital tract can help to understand and elucidate events related to tissue tropism, niche adaptation and pathogenesis of bovine genital campylobacteriosis (BGC), we investigated the chemotactic response of C. fetus subsp. venerealis and C. fetus subsp. fetus towards cervical mucus, bovine placenta and some of reported substances and ion of bovine cervical mucus and bovine placenta
Bovine cervical mucus was chemoattractant to all C. fetus strains evaluated, and no statistical difference was observed among the tested strains (Figure 3)
Summary
C. fetus subsp. venerealis and C. fetus subsp. fetus are important cause of reproductive disorders in cattle. Large economic losses occur due to decrease production of milk and calves, increase calving interval, and large number of open cows at the end of the breeding season (McCool et al, 1988; Pellegrin et al, 2002) Despite this great impact on animal health, the mechanisms involved in the pathogenesis of infection of the two C. fetus subspecies in cattle, especially regarding to tissue tropism, remains elusive. It has been speculated that tissue tropism of C. fetus subspecies is dictated by the presence of local substrates, as amino acids, Copyright © The Author(s)
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