Abstract
Abstract—Stimulant‐induced changes in soluble preparations from rabbit olfactory epithelium were monitored by ultraviolet difference spectroscopy. A time‐dependent decrease of absorbance, maximum at 267 nm, was generated when specific stimulants were mixed with the olfactory preparations. Only seven of the 37 organic chemicals tested generated the absorbance change at 267 nm. The olfactory preparations exhibited a high degree of selectivity and sensitivity; measurable absorbance changes were observed when the active stimulant concentrations were 1 × 10−5m. The experimental results suggest a complex mechanism of conformational change for the initial stimulant‐induced molecular interactions in biological chemosensing.
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