Abstract
An economical and eco-compatible synthetic protocol for chemoselective and regioselective reduction of nitroaromatics in water has been achieved using easily accessible alumina-supported nickel nanoparticles as a stable recyclable heterogeneous catalyst. Various sensitive substituents like allyloxy, benzyloxy, t-butyldimethylsilyloxy, hydroxymethyl, alkoxycarbonyl, formyl, keto, carboxylic acid, chloro, bromo, azo and cyano were tolerated in the aforesaid protocol. This method has been extended for the construction of imidazole derivatives through one-pot reductive condensation of 2-nitroaniline with diversely substituted benzaldehydes. Some of the synthesized imidazoles have been used as antibacterial, antiplatelet and antithrombotic agents.
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