Chemoselective Formal [4+2] Cycloaddition of 3‐Hydroxycyclobutanones with Enones

Abstract

Choice cuts: The formal [4+2] cycloaddition of 3-hydroxycyclobutanones to α,β-unsaturated ketones proceeds chemoselectively at the α,β-carbon–carbon double bond to afford cyclohexanone derivatives by using boron trifluoride etherate as a Lewis acid. In contrast, 3-ethoxycyclobutanone reacts at the carbonyl carbon–oxygen double bond to give dihydro-γ-pyrones. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.