Chemorobust dye-encapsulated framework as dual-emission self-calibrating ratiometric sensor for intelligent detection of toluene exposure biomarker in urine

Abstract

By taking advantages of confinement effect can effectively prevent dye aggregation caused luminescent quenching, Eosin Y (EY) was encapsulated into a chemorobust porous CoMOF as secondary fluorescent signal to construct the dual-emitting sensor of EY@CoMOF. And the photo-induced electron transfer from CoMOF to EY molecules induced EY@CoMOF presenting a weak blue emission at 421 nm and a strong yellow emission at 565 nm. Those dual-emission features also endow EY@CoMOF itself great potentials as a self-calibrating ratiometric sensor in visually and efficiently monitoring hippuric acid (HA) in urine, with fast response, high sensitivity and selectivity, excellent recyclable, and low LOD (0.24 μg/mL). Furthermore, based on a tandem combinational logic gate, an intelligent detection system was designed to improve the practicability and convenience of HA detection in urine. To the best of our knowledge, this is the first example of dye@MOF based sensor for HA detection. And this work provides a promising approach for developing dye@MOF based sensors to intelligent detect bioactive molecules.