Abstract
The chemoprotective effects of neem (Azadirachta indica A. Juss.) on hepatic and circulatory lipid peroxidation and on antioxidant and detoxifying enzyme status during 7, 12-dimethylbenz [a] anthracene (DMBA)-induced buccal pouch carcinogenesis was investigated in Syrian male hamsters. Enhanced lipid peroxidation in the liver and circulation of tumor-bearing animals was accompanied by a significant decrease in reduced glutathione (GSH) concentration and activities of the detoxifying enzymes glutathione peroxidase (GPx) and glutathione-S-transferase (GST). Administration of neem leaf extract significantly decreased the formation of lipid peroxides and enhanced the levels of antioxidants and detoxifying enzymes. We speculate that neem leaf extract exerts its effects by modulating lipid peroxidation and enhancing antioxidant and detoxification systems.
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