Abstract
The effect of betel leaf extract and some of its constituents, eugenol, hydroxychavicol, β-carotene and α-tocopherol, on benzo[ a]pyrene-induced foestomach neoplasia in male Swiss mice was examined. Betel leaf and its constituents decreased the number of papillomas per animal with the maximum protection, considering molar dosage, exhibited by β-carotene and α-tocopherol. Except for β-carotene, eugenol, hydroxychavicol and α-tocopherol increased the levels of reduced glutathione in the liver while glutathione S-transferase activity was enhanced by all except eugenol. Of seven sources, Banarasi betel leaves showed the maximum amounts of β-carotene and α-tocopherol.
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