Abstract
In the present study, the chemical profiling of methanol (MSC) and ethyl acetate (EASC) extracts of Sargassum cristaefolium was investigated using UPLC-ESI-Q-TOF-MSE analysis and the results showed the presence of 146 compounds belongs to various class of bioactive compounds. As well, the LC-QqQ-MS analysis was used to quantify the compounds present in the extracts of S. cristaefolium. The in vitro cytotoxic activity showed that the MSC and EASC have excellent growth inhibitory activity against prostate cancer and induce apoptosis in DU145 prostate cancer cells by generating oxidative stress and arresting the cell cycle progression via upregulating Bax, p53, and caspase 3. The in vivo analysis evidenced that the MSC and EASC inhibit tumor growth by upregulating the p53 and caspase 3 in BALB/c mice. Together, the compounds present in the solvent extracts of S. cristaefolium could be a potential source for the treatment of prostate cancer.
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