Abstract
Breast cancer is a predominant cause of death in women across the globe. Chemoprevention by using natural, dietary or synthetic products has been appearing to be a fascinating approach to combat the growing burden of breast cancer. In the current study, we intended to explore the mechanisms of chemopreventive action of honokiol against 7, 12 - dimethylbenz[a]anthracene (DMBA)-induced mammary cancer in female Sprague Dawlely (SD) rats. We induced mammary cancer in SD rats by administering single dose of DMBA (80 mg/kg) through intra gastric route. Chemopreventive effects of honokiol (80 mg/kg, i.p.) were confirmed from its ameliorating effect on the DMBA-induced anomalies such as liver marker enzymes, Phases I and II metabolizing enzymes and oxidative stress markers. Further, honokiol reversed the DMBA-induced abnormalities in inflammatory cytokines levels and serum tumor markers. Additionally, histopathological examination of mammary tissue and protein expression analysis of NF-κB revealed that honokiol is effective against DMBA-induced mammary cancer. In summary, the results of our study support the chemopreventive feature of honokiol in mammary cancer.
Highlights
Breast cancer is a complicated ailment that can precipitate due to anomalies in several physiological cell signaling pathways
Tumor developed in all the animals of DMBA control group (Group III) (p < 0.05); tumor development was decreased in the honokiol treated groups (Group IV)
We evaluated the preventive effect of honokiol against DMBA-induced mammary cancer in Sprague Dawlely (SD) rats
Summary
Breast cancer is a complicated ailment that can precipitate due to anomalies in several physiological cell signaling pathways. Breast cancer is an alarming global public health problem, as it is a key cause of illness and death in women. In the year 2016, breast cancer alone is anticipated to reach 29% all newly diagnosed cancers in women (Siegel et al, 2016). The National Central Cancer Registry of China reported that in China, after lung cancer breast cancer is the principal reason of cancer-related deaths in women younger than 45 years (Chen et al, 2016). There are various risk factors, which could be ascribed to breast cancer; among them predominant factors are genetic vulnerability (mutations in BRCA 1 and BRCA 2), exposure of radiation, overweight and obesity, and alcohol addiction. Breast cancer is associated with age and estrogen exposure. A steroidal hormone, principally estrogen, can cause the induction and growth
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