Abstract
The nutraceutical resveratrol (trans-3,4',5 Trihydroxystilbene) is a potent but non-toxic chemopreventive agent. Resveratrol arrested HNSCC cells, but not primary cells, in the S phase by damaging DNA, activating the checkpoint and producing apoptosis (Tyagi et al., 2005; 2011). We propose that resveratrol slows DNA replication by inhibition of DNA polymerase resulting in DNA replication fork breakage, damage and apoptosis in cancer cells that lack DNA repair and checkpoint pathways. Our pre-clinical studies are focused on HNSCC because of the possibility of using oral administration of resveratrol to prevent recurrence and secondary malignancies in HNSCC patients after radiation and/or chemotherapy.
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