Abstract
ObjectivesThe chemokine CXCL1, known as growth-related oncogene α (GRO-α), is a potent chemoattractant and regulator of neutrophils. The purpose of our study was to evaluate the regulatory response of CXCL1 in the serum of patients with systemic lupus erythematosus (SLE) in the active stage of disease and to assess whether it was implicated in the pathogenesis/inflammatory process in lupus.MethodsCXCL1 serum concentrations were examined in 90 SLE patients, 56 other autoimmune diseases (OADs) patients and 100 healthy controls using enzyme-linked immunosorbent methodology.ResultsSLE patients exhibited significant increases in serum CXCL1 concentrations [1492.86 (735.47–2887.34) pg/ml] compared with OADs patients [155.88 (10.77–366.78) pg/ml] and healthy controls [13.58 (8.46–37.22) pg/ml] (p < 0.001). Moreover, the level of CXCL1 decreased as the level of anti-dsDNA IgG decreased after treatment between the anti-dsDNA-positive SLE patients and the anti-dsDNA-negative SLE patients. Additionly, serum CXCL1 concentrations were related to different disease activity levels in SLE and lupus nephritis (LN) and high avidity of IgG ANAs (HA IgG ANAs) (p < 0.05). Furthermore, CXCL1 serum concentrations were significantly correlated with the SLE Disease Activity Index(SLEDAI) score, relative avidity index (RAI) of HA IgG ANAs and the levels of anti-dsDNA IgG, CRP, ESR, albumin, C3 and C4.Additionally, Statistical analysis revealed that positivity for IgG ANA (p < 0.001), the presence of HA IgG ANAs (p = 0.001) and the logarithmic level of anti-dsDNA IgG (p = 0.021) were significantly associated with the logarithmic level of CXCL1 with standard partial regression coefficients (95% CI) of 2.371 (1.734–3.009), 1.231 (0.52–1.937) and 0.409 (0.062–0.755), respectively. Finally, using cutoff points of 1182.17 pg/mL and 1500.31 pg/mL, serum CXCL1 levels had a similar sensitivity of 76% and specificity of 100% and 75% for the diagnosis of active SLE and LN, respectively.ConclusionsSerum CXCL13 concentrations might represent a potential marker of disease activity in systemic lupus erythematosus.
Highlights
Systemic lupus erythematosus (SLE) is a common autoimmune disease involving multiple organs and systems
CXC ligand 1 (CXCL1), anti-dsDNA IgG, C-reactive protein (CRP), erythrocyte sedimentation ratio (ESR), albumin, complement molecules C3 and C4, and neutrophil serum levels differed among the three study groups (p < 0.05)
Significant increases in CXCL1 serum levels were observed in the SLE group [1492.86 (735.47–2887.34) pg/ml] compared with the other autoimmune diseases (OADs) group [174.23 (17.07–368.40) pg/ml] (p < 0.001) and healthy controls [13.58 (8.46–37.22) pg/ml] (p < 0.001)
Summary
Systemic lupus erythematosus (SLE) is a common autoimmune disease involving multiple organs and systems. Wang et al [12] reported that in a murine model of lupus, pristane-treated wild-type (WT) mice exhibited elevated CXCL1, MCP-1, antisnRNP and anti-dsDNA levels compared with untreated mice; CXCL1, MCP-1 and anti-snRNP levels were reduced in pristane-treated P-selectin glycoprotein ligand-1-deficient (Psgl-1−/−) mice compared to pristane-treated WT mice. These results verified that CXCL1 may be involved in the course of SLE, especially LN, and that CXCL1 is an important factor that regulates active leukocyte recruitment into inflamed tissue. In the case of lupus nephritis, the temporal course of the event is believed to place the production of chemokines at a very early moment in the disease process, which is consistent with their proposed role as an early mediator of renal inflammation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
