Abstract

In article number 2100006, Wen Sun, Wen-fei Dong, Dan Shao, and co-workers fabricate diselenide-bridged mesoporous organosilica nanoparticles for coordination and redox dual-responsive delivery of chemotherapeutic ruthenium compound KP1339. Such immunogenic cell death nano-amplifier performed robust suppression on primary and distant tumor growth, as well as pulmonary metastasis of breast cancer with low systematic toxicity when combined with anti-PD-L1.

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