Abstract
Four tricyclic lactams that structurally resemble alkaloids with the pancratistatin skeleton were synthetized from bromobenzene by a chemoenzymatic strategy. The sequence involved enzymatic dihydroxylation, efficient stereodirected oxidation of double bonds, inter‐ or intramolecular Huisgen cycloaddition, and a solvent‐free cyclization. The complex structures were obtained in high chemical and optical purity and may be good candidates for biological testing.
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