Abstract
New 3-azabicyclo[3.2.0]heptane derivatives were synthesized using a multicomponent reaction. Racemic compounds were efficiently resolved by kinetic resolution with immobilized lipase B of Candida antarctica (Novozym 435). The obtained compounds demonstrated greater binding affinity at D2L and D3 dopamine receptors compared to D1 binding sites, and individual enantiomers of the same compound possessed distinct affinities.
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