Abstract
Oxathiaaza[3.3.3]propellane derivatives were prepared by reaction of in situ generated asymmetric thioureas with intermediate Knoevenagel adducts resulting from ninhydrin and malononitrile. This four-component sequential transformation performed in one reaction flask represents a general route to this unexplored valuable class of sulfur–nitrogen heterocycles. The chemoselectivity and regiochemistry of the products were established by IR, NMR and single crystal X-ray analysis.
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