Abstract
Aromatic rings are important in medicines and agricultural products, but attaching functional groups to them is a persnickety process. Chemists can only add substituents at specific positions on the ring, and this can take multiple steps that require complex ingredients and give a mixture of products that are hard to separate. Now chemists from and ’s group at the University of Manchester have worked out a one-pot cascade reaction to make anilines—benzene compounds attached to an amino group—without having to mess with finicky aromatic-ring chemistry ( 2020, DOI: ). “Our idea was to go as far away as possible from aromatic chemistry,” Leonori says. His team decided to start with an amine and a cyclohexanone, two molecules that don’t have any carbon–carbon double bonds. Their reaction happens in a single pot at near room temperature, but it goes through several steps to ultimately get the aniline. First, the amine and
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