Abstract

Since quinazolone-4 was first synthesized in 1885 by Griess andWeddige,a number of its derivatives with one or more substituted groupson the nucleus has been prepared.In most cases,the substituents were intro-duced before or during the process of formation of the pyrimidine ring.Onaccount of the rather low reactivity of the quinazolone molecule toward sub-stitution,only a few substitution reactions have been studied and very littlehas been known about the orientation of the entering groups.Thus,Bogertet al.studied the bromination and nitration of quinazolone and its...

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