Abstract
The new vitamin D analog KH-1060 has immunosuppressive activity greater than of cyclosporin A. We report a new CD synthon 4 for the vitamin D analog KH-1060 and the synthesis and x-ray structure of related cholesterol derivative 15. Williamson ether synthesis provides a route to this class of compound using a new CD intermediate 8. The x-ray structure of 14 suggests that the immunosuppressive activity of KH-1060 may lie in its unique steroid side chain geometry.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
