Abstract
The acid-catalysed degradations of the potent antitumour and antiviral sponge metabolite mycalamide A and a triacetyl derivative have been examined. Acetal exchange reactions, catalytic hydrogenation, epoxidation and oxidation reactions have also been performed on mycalamides A and B. The major products derived from these reactions were characterised and tested for in vitro P388 anti-leukaemia activity and structure–activity relationships were deduced from these results.
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