Abstract
Homologous and isomeric series of thiazole derivatives of isoflavones were produced on the basis of α-(4-methyl-2-thiazolyl)-2-hydroxyacetophenones. A study of α-(4-methyl-2-thiazoyl)-2-hydroxyacetophenones by PMR spectroscopy showed that these compounds exist in most nonpolar and low polarity organic solvents exclusively in the ketone form, but in dimethyl sulfoxide solution both the ketone and enol forms are observed in various ratios. A simple and effective preparative method of synthesis of homologs of 3-(2-diazolyl)-chromones was developed, and their alkylation at the phenolic hydroxyl was studied. Data of biological tests of the compounds synthesized are presented.
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