Abstract
AbstractHypusine, an unusual amino acid, is derived from the hydrolysis of eukaryotic initiation factor 5 A (eIF‐5A), the only cellular protein known to contain hypusine residue. Hypusine residue is formed through a spermidine‐dependent posttranslational modification of eIF‐5A at a specific lysine residue. Each mature eIF‐5A molecule contains only one hypusine. Hypusine formation on eIF‐5A is essential for cell survival and proliferation. The biochemistry of hypusine formation has been actively investigated in a number of leading laboratories during the past decade. The precise functional role of eIF‐5A remains a mystery. This paper reviews recent progress in the study of the biochemistry of hypusine formation and offers speculation on the possible function of eIF‐5A.
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