Abstract
Isoxazole analogs of isoflavones have been synthesized by the cyclization of α-(3-isoxazolyl)-2-hydroxyacetophenones. Their alkylation, acylation, and electrophilic substitution reactions, and reactions with binucleophiles have been studied. 3-(3-Isoxazolyl)-7-methoxychromones are rearranged selectively into 2-aminochromone derivatives by the action of hydroxylamine as a result of a double recyclization and are recyclized into pyrazole derivatives by hydrazine. Preparations with hypolipidemic, anabolic, hypoglycemic, and antiarrhythmic action are found among the derivatives of 3-(3-isoxazolyl)chromones.
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