Abstract
A one-pot annulation reaction of aniline and its ring-sub- stituted derivatives with 1,1,2-trichloro-2-nitroethene (TCNiE) was developed delivering 3-chloroquinoxalin-2(1H)-one 4-oxides, ex- clusively, in good yields. The structure was proved by X-ray analy- sis. The C-N cyclization, a competing reaction to the double SNVin reaction of 1,1,2-trichloro-2-nitroethene with amines, can be con- trolled by the mode of addition. Some of the resulting quinoxalin- ones are promising candidates with respect to their prospective biological, especially pharmacological, activity.
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