Abstract
Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species (Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially, mono- and di-acids, solubilized by sesquiterpene hydrocarbons. The sesquiterpenes and diterpenes (labdane, clerodane and kaurane skeletons) are different for each Copaifera species and have been linked to several reported biological activities, ranging from anti-tumoral to embriotoxic effects. This review presents all the substances already described in this oleoresin, together with structures and activities of its main terpenoids.
Highlights
The Copaiba oleoresin is obtained from the trunk of several Copaifera L. species (Leguminosae-Caesalpinoideae)
Jr. et al [14] evaluated the anti-inflammatory activity of three different copaiba oleoresins (C. multijuga Hayne, C. cearensis Huber ex Ducke and C. reticulata Ducke), and demonstrated that similar in composition, they showed different activities
The results of this study suggest that the copaiba oleoresin may be a potential source of new and selective antimicrobial agents [22]
Summary
The Copaiba oleoresin is obtained from the trunk of several Copaifera L. species (Leguminosae-Caesalpinoideae). These trees are native to the tropical regions of Latin America and Western Africa. Copaiba oleoresin is widely used as a popular medicine, through topical and oral administration. It has various ethnopharmacological indications, including: gonorrhea, bronchitis, pains in general, back pain, injury, blennorrhagia, leucorrhea, psoriasis, “catarro da bexiga”, wounds, asthma, as an antiseptic for wounds, skin ulcers, aching joints, ovarian cysts, uterine myoma, weak uterus, vaginal discharge, ovarian problem, ulcers, sore throat, uterine infections, general inflammations, as a tonic and to treat ulcers and other digestive diseases, and cancer, and leishmanioses [4,5,6,7,8,9,10,11,12]. This study aims to expand knowledge about the chemical composition, biological activities and pharmacological actions of copaiba oleoresin and its major constituents
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