ChemInform Abstract: Triflic Anhydride Mediated Ring‐Opening/Recyclization Reaction of α‐Carbamoyl α‐Oximyl Cyclopropanes with DMF: Synthetic Route to 5‐Aminoisoxazoles.

Abstract

A facile and efficient synthesis of fully substituted 5-amino­isoxazoles was developed from α-cyclopropyl β-oximyl amides in the presence of triflic anhydride (Tf2O) in DMF under very mild conditions. The process involves sequential ring-opening and intramolecular cyclization reactions.